alteplase

Action

Directly converts plasminogen to plasmin, which then degrades clot-bound fibrin.

Therapeutic Effect(s):

• Lysis of thrombi in coronary arteries, with improvement of ventricular function, and reduced risk of heart failure or death.
• Lysis of pulmonary emboli.
• Lysis of thrombi causing ischemic stroke, reducing risk of neurologic sequelae.
• Restoration of cannula or catheter function.