Directly converts plasminogen to plasmin, which then degrades clot-bound fibrin.
- Lysis of thrombi in coronary arteries, with improvement of ventricular function, and reduced risk of heart failure or death.
- Lysis of pulmonary emboli.
- Lysis of thrombi causing ischemic stroke, reducing risk of neurologic sequelae.
- Restoration of cannula or catheter function.