Contraindication/Precautions

Contraindicated in:

• Hypersensitivity; cross-sensitivity with other NSAIDs may exist

• History of Aspirin Triad (nasal polyps, asthma, bronchospasm following aspirin)

• Treatment of perioperative pain following coronary artery bypass graft (CABG) surgery

• Advanced renal disease

• Application to non-intact or damaged skin

• OB: Late pregnancy (may cause premature closure of the ductus arteriosus) or lactation

• Geri: Increased risk of adverse effects; consider age-related decrease in metabolic pathways, concurrent disease states and drug therapy

• History of cardiovascular disease or risk factors (increased risk of serious cardiovascular effects)

• History of hypertension or edema (may exacerbate condition)

• History of impaired renal or hepatic function, heart failure, concurrent ACE inhibitor or diuretic therapy (increased risk of renal toxicity)

• Chronic corticosteroid therapy (slow tapering of corticosteroids required)

• Bleeding abnormalities or platelet dysfunction

• Pedi: Safe use not established

• History of ulcer disease or GI bleeding

• Pre-existing asthma

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