Implementation

May switch to appropriate oral therapy after at least 3 days of parenteral therapy, once clinical improvement has been demonstrated

IV Adminstration:

• Intermittent Infusion:
Reconstitute 500-mg vial with 10 mL of sterile injection or 0.9% NaCl and shake gently to form a suspension of 50 mg/mL.
Diluent: Withdraw the resulting solution using a 21–gauge needle and add it to 100 mL of 0.9% NaCl or D5W; gently shake until clear. For moderate or severe renal impairment, withdraw 55 mL of this solution from the bag and discard. Solution should be clear and colorless to slightly yellow.
Concentration: Final concentration is 4.5 mg/mL. Suspension is stable for 1hr prior to dilution in infusion bag. Administer within 8 hr of reconstitution with 0.9% NaCl or 4 hrs of reconstitution with D5W at room temperature or 24 hr if refrigerated; do not freeze

• Rate:
Administer over 1 hr. Do not administer direct IV

• Y-Site Incompatibility:
Do not mix with or physically add to solutions containing other medications

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