Assessment

• Assess patient for infection (vital signs; appearance of wound, sputum, urine, and stool; WBC) at beginning of and during therapy

• Obtain a history before initiating therapy to determine previous use of and reactions to penicillins, cephalosporins or carbapenems. Persons with a negative history of penicillin sensitivity may still have an allergic response

• Obtain specimens for culture and sensitivity before initiating therapy. First dose may be given before receiving results

• Observe patient for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing). Discontinue the drug and notify the physician immediately if these occur. Have epinephrine, an antihistamine, and resuscitative equipment close by in the event of an anaphylactic reaction.

• May cause AST, ALT, serum alkaline phosphatase levels

» May cause anemia

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