Adverse Reactions/Side Effects

CNS: fatigue, weakness, dizziness, headache, insomnia.

EENT: lacrimation.

CV: chest pain, edema, myocardial ischemia, ventricular dysfunction.

Resp: dyspnea.

GI: abdominal pain , anorexia*, constipation, diarrhea, mucositis, nausea, stomatitis, vomiting, altered taste.

Derm: alopecia, hyperpigmentation, nail disorder, palmar-plantar erythrodysesthesia (combination therapy with capecitabine), exfoliation, pruritus, rash, hot flushes.

Hemat: MYELOSUPPRESSION.

MS: arthralgia, musculoskeletal pain, myalgia.

Neuro: peripheral neuropathy.

Misc: hypersensitivity reactions.

*CAPITALS indicates life-threatening.
*italic indicates most frequent.
*CAPITALS/italic indicates life-threatening and most frequent.

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