Pharmacokinetics

Absorption: Well absorbed following oral administration

Distribution: Unknown

Protein Binding: 98%

Metabolism and Excretion: Mostly metabolized by the liver, including the CYP2D6 enzyme system; some have antihypertensive action; minimal excretion of unchanged drug

Half-life: Extensive metabolizers—12 hr; poor metabolizers—19 hr

TIME/ACTION PROFILE (blood levels)

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