Action

• Piperacillin: Binds to bacterial cell wall membrane, causing cell death. Spectrum is extended compared with other penicillins

• Tazobactam: Inhibits beta-lactamase, an enzyme that can destroy penicillins

Therapeutic Effect(s):
Death of susceptible bacteria

Spectrum:
Active against piperacillin-resistant, beta-lactamase–producing

» Bacteroides fragilis

» E. coli

» Acinetobacter baumanii

» Klebsiella pneumoniae

» Pseudomonas aeruginosa

» Staphylococcus aureus

» Haemophilus influenzae

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