Pharmacokinetics

Absorption: Piperacillin is well absorbed (80%) from IM sites

Distribution: Widely distributed. Enter CSF well only when meninges are inflamed. Cross the placenta and enter breast milk in low concentrations

Metabolism and Excretion: Piperacillin (68%) and tazobactam (80%) are mostly excreted unchanged by the kidneys

Half-life: 0.7–1.2 hr

TIME/ACTION PROFILE (piperacillin blood levels)

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