Patient/Family Teaching

• Advise patient to notify health care professional immediately if any new or worsening abdominal pain or blood in stools occur or if signs of bowel perforation (fever, abdominal pain, metabolic acidosis, bloody stools, diarrhea) occur.

• Advise patient to avoid drinking grapefruit juice while taking temsirolimus

• Advise patients to notify health care professional if excessive thirst or volume or frequency of urination and diabetic patients to closely monitor glucose

• Inform patient of the increased risk for intracerebral bleeding with temsirolimus

• Advise patient to consult health care professional prior to taking any Rx, OTC, or herbal products, especially St. John's Wort

• Instruct patient not to receive any vaccinations without advice of health care professional and to avoid contact with persons who have received live vaccines during therapy

• Advise female patients to avoid becoming pregnant during and for 3 months after therapy. Men with partners of child-bearing potential should use reliable contraception throughout therapy and for 3 months after last dose of temsirolimus

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