Pharmacokinetics
Absorption: IV administration results in complete bioavailability
Distribution: Temsirolimus and sirolimus partition extensively in formed blood elements
Metabolism and Excretion: Mostly metabolized by the liver to sirolimus, an active metabolite Primarily eliminated in feces
Half-life: Temsirolimus—17.3 hr; sirolimus—54.6 hr
TIME/ACTION PROFILE
| ROUTE | ONSET | PEAK | DURATION |
| IV | unknown | end of infusion | 1 wk |
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