Pharmacokinetics

Absorption: IV administration results in complete bioavailability

Distribution: Rapidly distributes into total extracellular space

Metabolism and Excretion: Mostly degraded by lysosomal enzymes. Small amounts (9%) are excreted unchanged by the kidneys

Half-life: 150 min (postdistribution); 10 hr (terminal elimination)

TIME/ACTION PROFILE (effects on bleeding)

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