Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Active liver disease, including unexplained elevations in liver function tests

• Concurrent use of cyclosporine or lopinavir/ritonavir

• Severe renal impairment (CCr <30 mL/min)

• OB: Pregnancy or women who may become pregnant

• Lactation: Breastfeeding should be avoided

• Renal impairment (↑ risk of myopathy, dosage reduction recommended for CCr 30–<60 mL/min)

• Hypothyroidism, concurrent use of fibrates or lipid-lowering doses of niacin (↑ risk of myopathy)

• Geri: ↑ risk of myopathy (age >65 yr)

• History of alcohol abuse or moderate alcohol consumption (↑ risk of liver damage)Pedi: Safe and effective use in children not established

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