Stimulates bladder afferent pathways, causing release of nitrogen oxide from afferent neurons which controls lower urinary tract function. Also has anti-inflammatory, anti-ischemic analgesic, and vasodilatory properties.
Improved symptoms of interstitial cystitis.
Prevention of tissue necrosis from extravasation injuries.
Absorption: Easily penetrates the skin.
Distribution: Widely distributed in body fluids and tissues.
Metabolism and Excretion: Metabolized to dimethyl sulfone and dimethyl sulfide.
|PO, Topical, Intravesicular||unknown||4 hr||unknown|
OB: Pregnancy and lactation.
Use Cautiously in:
Adverse Reactions/Side Effects
CNS: sedation, headache, dizziness.
Derm: pruritus, dry skin.
GI: nausea, vomiting, diarrhea.
GU: bladder discomfort.
Misc: garlic-like breath/body odor.
*CAPITALS indicates life-threatening.
*italic indicates most frequent.
May ↓ effectiveness of sulindac .
Natural Products-Natural Products
Topical (Adults): Interstitial cystitisInstill 50 mL of aqueous 50% dimethyl sulfoxide solution into the bladder up to every 2 wk; Extravasation injury7790% DMSO applied topically every 38 hrs..
PO (Adults): Amyloidosis715 grams daily..
Assess for symptoms of interstitial cystitis (suprapubic pain, urinary frequency, nocturia hematuria) prior to and periodically during therapy.
Potential Nursing Diagnoses
Intravesical: Instill 50 mL of 50% solution into the bladder. Instruct patient to retain solution of 1560 min.
Instruct patient as to what to expect during therapy. Advise patient to notify health care professional if symptoms worsen or if changes in symptoms occur.
Decrease in symptoms of interstitial cystitis.
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