rivaroxaban

Contraindication/Precautions

Contraindicated in:

• Hypersensitivity;

• Active major bleeding;

• Severe renal impairment (CCr <30 mL/min);

• Moderate to severe hepatic impairment (Child-Pugh B or C) or any liver pathology resulting in altered coagulation;

• Lactation: Avoid breast-feeding;

• Concurrent P-gp inhibitor/CYPA4 inducers (avoid if possible).

• Neuroaxial spinal anesthesia or spinal puncture, especially if concurrent with an indwelling epidural catheter, drugs affecting hemostasis, history or traumatic/repeated spinal puncture or spinal deformity (↑ risk of spinal hematoma);

• Use of feeding tube (proper placement of tube must be documented in insure absorption).