Active major bleeding;
Severe renal impairment (CCr <30 mL/min);
Moderate to severe hepatic impairment (Child-Pugh B or C) or any liver pathology resulting in altered coagulation;
Lactation: Avoid breast-feeding;
Concurrent P-gp inhibitor/CYPA4 inducers (avoid if possible).Use Cautiously in:
Neuroaxial spinal anesthesia or spinal puncture, especially if concurrent with an indwelling epidural catheter, drugs affecting hemostasis, history or traumatic/repeated spinal puncture or spinal deformity (↑ risk of spinal hematoma);
Use of feeding tube (proper placement of tube must be documented in insure absorption).