fidaxomicin

Pharmacokinetics

Absorption: Minimal systemic absorption.

Distribution: Stays primarily in the GI tract.

Metabolism and Excretion: Mostly transformed via hydrolysis in the GI tract to OP-1118, its active metabolite. Eliminated mostly (>92%) in fece: <1% excreted in urine.

Half-life: Fidaxomicin—11.7 hr; OP-1118—11.2 hr.

TIME/ACTION PROFILE