↑ risk of serious adverse cardiovascular effects with MAO inhibitors , tricyclic antidepressants , drugs that prolong the QTc interval ; use with extreme caution.
Effectiveness may be ↓ by beta-blockers; use cautiously and only when necessary.
Concurrent use with other adrenergics may ↑ adrenergic adverse reactions (↑ heart rate, BP, jitteriness).
↑ risk of hypokalemia or ECG changes with xanthine derivatives , corticosteroids , diuretics , or non-potassium sparing diuretics .Drug-Natural Products
Use with caffeine-containing herbs ( cola nut , guarana , mate , tea , coffee ) ↑ stimulant effect.