Contraindication/Precautions

Contraindicated in:

• Hypersensitivity to abciximab or murine (mouse) protein

• Active internal bleeding

• Recent significant GI or GU bleeding (within 6 wk)

• History of CVA (within 2 yr) or CVA with neurologic sequelae

• History of bleeding disorder

• Recent (within 7 days) oral anticoagulant therapy (PT >=1.2 times control)

• Platelet count <100,000 cells/mm³

• Recent trauma or major surgery (within 6 wk)

• Intracranial neoplasm

• Aneurysm or AV malformation

• Severe uncontrolled hypertension

• History of vasculitis

• Concurrent use of another parenteral GP IIb/IIIa inhibitor

• Recent or concurrent dextran therapy

• Patients weighing <75 kg or >65 yr (increased risk of bleeding)

• History of previous GI pathology

• Concurrent thrombolytic or heparin therapy

• PCI within 12 hr of onset of MI symptoms or PCI procedure lasting >70 min

• OB: Lactation: Pedi: Safety not established

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