- Advise patient to take medication exactly as directed and not to take more than the recommended amount. Chronic excessive use of > 4 g/day (2 g in chronic alcoholics) may lead to hepatotoxicity, renal or cardiac damage. Adults should not take acetaminophen longer than 10 days and children not longer than 5 days unless directed by health care professional. Short-term doses of acetaminophen with salicylates or NSAIDs should not exceed the recommended daily dose of either drug alone.
- Advise patient to avoid alcohol (3 or more glasses per day increase the risk of liver damage) if taking more than an occasional 1–2 doses and to avoid taking concurrently with salicylates or NSAIDs for more than a few days, unless directed by health care professional.
- Pedi: Advise parents or caregivers to check concentrations of liquid preparations. Errors have resulted in serious liver damage. Have parents or caregivers determine the correct formulation and dose for their child (based on the child's age/weight), and demonstrate how to measure it using an appropriate measuring device.
- Inform patients with diabetes that acetaminophen may alter results of blood glucose monitoring. Advise patient to notify health care professional if changes are noted.
- Caution patient to check labels on all OTC products. Advise patients to avoid taking more than one product containing acetaminophen at a time to prevent toxicity.
- Advise patient to consult health care professional if discomfort or fever is not relieved by routine doses of this drug or if fever is greater than 39.5°C (103°F) or lasts longer than 3 days.
acetaminophen (oral, rectal) is a sample topic found in Davis's Drug Guide.
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