Interactions

Drug-Drug

• Chronic high-dose acetaminophen (>2 g/day) may ↑ risk of bleeding with warfarin (PT should be monitored regularly and INR should not exceed 4)

• Hepatotoxicity is additive with other hepatotoxic substances , including alcohol

• Concurrent use of sulfinpyrazone , isoniazid , rifampin , rifabutin , phenytoin , barbiturates , and carbamazepine may ↑ the risk of acetaminophen-induced liver damage (limit self-medication); these agents will also ↓ therapeutic effects of acetaminophen

• Concurrent NSAIDs ↑ the risk of adverse renal effects (avoid chronic concurrent use)

• Propranolol ↓ metabolism and may ↑ effects

• May ↓ effects of lamotrigine and zidovudine

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