Interactions

Drug-Drug

• Chronic high-dose acetaminophen (>2 g/day) may risk of bleeding with warfarin (PT should be monitored regularly and INR should not exceed 4)

• Hepatotoxicity is additive with other hepatotoxic substances, including alcohol

• Concurrent use of sulfinpyrazone, isoniazid, rifampin, rifabutin, phenytoin, barbiturates, and carbamazepine may the risk of acetaminophen-induced liver damage (limit self-medication); these agents will also therapeutic effects of acetaminophen

• Concurrent NSAIDs the risk of adverse renal effects (avoid chronic concurrent use)

• Propranolol metabolism and may effects

• May effects of lamotrigine and zidovudine

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