Pharmacokinetics
Absorption: Dose dependent; erratic with doses >10 mg/kg/day
Distribution: Crosses the placenta and blood-brain barrier; enters breast milk
Protein Binding: 95%
Metabolism and Excretion: Excreted mostly unchanged in urine
Half-life: 2.4–5.8 hr
TIME/ACTION PROFILE (lowering of intraocular pressure)
| ROUTE | ONSET | PEAK | DURATION |
| PO | 1–1.5 hr | 2–4 hr | 8–12 hr |
| PO-ER | 2 hr | 8–18 hr | 18–24 hr |
| IV | 2 min | 15 min | 4–5 hr |
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