Contraindication/Precautions

Contraindicated in:

• Hypersensitivity or cross-sensitivity with sulfonamides may occur

• Hepatic disease or insufficiency

• Concurrent use with ophthalmic carbonic anhydrase inhibitors (brinzolamide, dorzolamide) is not recommended

• OB: Avoid during first trimester of pregnancy

• Chronic respiratory disease

• Electrolyte abnormalities

• Gout

• Renal disease (dosage reduction necessary for ClCr <50 ml/min)

• Diabetes mellitus

• OB: Use with caution during second or third trimester of pregnancy

• Lactation: Safety not established

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