Route/Dosage

• PO (Adults):
Glaucoma (open angle)—250–1000 mg/day in 1–4 divided doses (up to 250 mg q 4 hr) or 500-mg extended-release capsules twice daily.
Epilepsy—4–16 mg/kg/day in 1–4 divided doses (maximum 30 mg/kg/day or 1 g/day).
Altitude sickness—250 mg 2–4 times daily started 24–48 hr before ascent, continued for 48 hr or longer to control symptoms.
Antiurolithic—250 mg at bedtime.
Edema—250–375 mg/day.
Urine alkalinization—5 mg/kg/dose repeated 2–3 times over 24 hrs.

• PO (Children):
Glaucoma—8–30 mg/kg (300–900 mg/m²/day) in 3 divided doses (usual range 10–15 mg/kg/day).
Edema—5 mg/kg/dose once daily.
Epilepsy—4–16 mg/kg/day in 1–4 divided doses (maximum 30 mg/kg/day or 1 g/day).

• PO (Neonates):
Hydrocephalus—5 mg/kg/dose q 6 hrs increased by 25 mg/kg/day up to a maximum of 100 mg/kg/day.

• IV (Adults):
Glaucoma (closed angle)—250–500 mg, may repeat in 2–4 hr to a maximum of 1 g/day.
Edema—250–375 mg/day.

• IV (Children):
Glaucoma—5–10 mg/kg q 6 hr, not to exceed 1 g/day.
Edema— 5 mg/kg/dose once daily.

• IV (Neonates):
Hydrocephalus—5 mg/kg/dose q 6 hrs increased by 25 mg/kg/day up to a maximum of 100 mg/kg/day.

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