Pharmacokinetics

Absorption: Well absorbed following oral administration

Distribution: Unknown

Protein Binding: 65–90% bound to plasma proteins

Metabolism and Excretion: Mostly metabolized by the liver; some conversion to hydroxyhexamide, which also lowers blood sugar

Half-life: Acetohexamide—1.3 hr (up to 30 hr in renal impairment); hydroxyhexamide—4.6–6 hr

TIME/ACTION PROFILE (hypoglycemic activity)

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