Interactions

Drug-Drug

• Ingestion of alcohol may result in disulfiram-like reaction

• Effectiveness may be by concurrent use of calcium channel blockers, cholestyramine, corticosteroids, diazoxide, estrogens, phenytoin, isoniazid, hormonal contraceptives, loop diuretics, phenothiazines, rifampin, sympathomimetics, thiazide diuretics, thyroid hormones, and urinary alkalinizers

• beta blockers, chloramphenicol, fluconazole, gemfibrozil, histamine H2 receptor antagonists, methyldopa, MAO inhibitors, NSAIDS, probenecid, salicylates, sulfonamides, tricyclic antidepressants, and urinary acidifiers may the risk of hypoglycemia

• Concurrent use with warfarin may alter the response to both agents ( effects of both initially, then activity; close monitoring recommended during any changes in dosage)

• Glucosamine may worsen hypoglycemia

• Fenugreek, chromium, and coenzyme Q-10 may produce hypoglycemic effects

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