Route/Dosage

• PO (Adults): 250 mg once daily; dose can be increased as needed by 250–500 mg daily every 5–7 days (not to exceed 1.5 g/day; doses >1 g/day should be given as divided doses).
Geriatric patients or hepatic insufficiency—dosage reduction may be required;
renal dysfunction (CCr < 50 ml/min)—use not recommended (increased risk of hypoglycemia).

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