Davis's Drug Guide

acetohydroxamic acid

Action

Reversibly inhibits the bacterial enzyme urease, which results in decreased hydrolysis of urea and subsequent production of ammonia in urine infected with urea-splitting bacteria

Therapeutic Effect(s):

• Decreased urinary ammonia levels and decreased urine pH, which increases the efficacy of anti-infective therapy and cure rates

• Does not directly alter pH or have any direct antibacterial activity



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