Pharmacokinetics

Absorption: Well absorbed following oral administration

Distribution: Distributed throughout body water

Metabolism and Excretion: 36–65% excreted unchanged in urine

Half-life: 5–10 hr (increased in renal impairment)

TIME/ACTION PROFILE (effect on urine)

ROUTE	ONSET	PEAK	DURATION
PO	4–8 hrs	0.25–1 hr†	6–8 hr

†Blood levels

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