Contraindication/Precautions

Contraindicated in:

• Urinary tract infection with non-urea-splitting organisms

• Urinary tract infections that can be controlled by culture-specific oral antibiotics

• Serum creatinine >2.5 mg/dl or CCr<20 ml/min

• OB: Causes birth defects; women of childbearing potential must use adequate contraception

• Lactation: Safety not established

• Renal impairment (increased risk of adverse reactions; dosage reduction recommended)

• Hepatic impairment

• Pre-existing thrombophlebitis or phlebothrombosis (increased risk of adverse reactions)

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