Pharmacokinetics

Absorption: Absorbed from the GI tract following oral administration. Action is local following inhalation; remainder may be absorbed from pulmonary epithelium

Distribution: Crosses the placenta; 0.47 L/kg

Protein Binding: 83% bound to plasma proteins

Metabolism and Excretion: Partially metabolized by the liver, 22% excreted renally

Half-life: Adults — 5.6 hr ( in hepatic impairment)newborns — 11 hr

TIME/ACTION PROFILE

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