Route/Dosage

Acetaminophen Overdose

• PO (Adults and Children): 140 mg/kg initially, followed by 70 mg/kg q 4 hr for 17 additional doses.

• IV (Adults and Children):
Loading dose —150 mg/kg over 15 min initially followed by
First maintenance dose —50 mg/kg over 4 hr, then
second maintenance dose —100 mg/kg over 16 hr.

• Inhaln (Adults and Children):
Nebulization via face mask—3–5 ml of 20% solution or 6–10 ml of the 10% solution 3–4 times daily (range —1–10 ml of 20% solution or 2–20 ml of 10% solution q 2–6 hr);
nebulization via tent or croupette—volume of 10–20% solution required to maintain heavy mist;
direct instillation—1–2 ml of 10–20% solution q 1–4 hr;
intratracheal instillation via tracheostomy—1–2 ml of 10–20% solution q 1–4 hr (up to 2–5 ml of 20% solution via tracheal catheter into particular segments of the bronchopulmonary tree).

• PO (Adults): 600 mg twice daily for 2 days, beginning the day before the procedure.

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