Implementation

• Therapy in women of childbearing age is started during the first 5 days of the menstrual period immediately preceding therapy, following 2 negative serum or urine pregnancy tests with a sensitivity of at least 25 mIU/ml. The first pregnancy test is used as a screening test and done at time of decision of acitretin therapy. Patients must commit to using 2 forms of birth control for at least 1 month prior to starting therapy, during therapy, and for at least 3 years after discontinuing therapy. For patients with ammenorrhea, the second pregnancy test is done 11 days after unprotected sexual intercourse. Continue pregnancy tests monthly during therapy

» A Patient Agreement/Informed Consent must be signed by female patients before receiving prescription. Limited amounts of acitretin should be prescribed to encourage compliance with pregnancy testing. All patients must receive a Soriatane Medication Guide with each prescription refill

• PO: Absorption is enhanced by taking with food

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