Pharmacokinetics

Absorption: Well absorbed (72%) following oral administration

Distribution: Crosses the placenta; remainder of distribution unknown

Protein Binding: Highly protein bound (99.9%)

Metabolism and Excretion: Mostly metabolized by the liver; metabolites excreted in feces (34–54%) and urine (16–53%)

Half-life: 49–63 hr

TIME/ACTION PROFILE (antipsoriatic effect)

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