Assessment

• Assess skin lesions before and periodically during therapy. Transient worsening of psoriasis, with increased redness and itching, may occur at initiation of therapy

• Monitor liver function (AST, ALT, and LDH) every 1–2 wk until stable and periodically thereafter as indicated. Discontinue therapy if hepatotoxicity is suspected

» Monitor fasting blood lipids (cholesterol, HDL, triglycerides) every 1–2 wk until lipid response to the drug is established, usually 4–8 wk, and periodically thereafter. Report cholesterol and triglyceride levels or in HDL

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