Pharmacokinetics

Absorption: Despite poor absorption (15–30%), therapeutic blood levels are achieved

Distribution: Widely distributed. CSF concentrations are 50% of plasma. Crosses placenta; enters breast milk

Protein Binding: <30%

Metabolism and Excretion: >90% eliminated unchanged by kidneys; remainder metabolized by liver

Half-life: Neonates: 4 hr; Children 1–12 yr: 2–3 hr; Adults: 2–3.5 hr ( in renal failure)

TIME/ACTION PROFILE (antiviral blood levels)

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