Pharmacokinetics

Absorption: 64% absorbed after subcut administration

Distribution: Synovial fluid concentrations are 31–96% of serum

Metabolism and Excretion: Unknown

Half-life: 14 days (range 10–20 days)

TIME/ACTION PROFILE (improvement)

ROUTE	ONSET	PEAK	DURATION
Subcut	8–26 wk	131 hr*	2 wk†

*Blood level
†Following discontinuation

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