Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Concurrent use of anakinra

• Active infection (including chronic or localized)

• Lactation: Potential for serious side effects in the infant; discontinue drug or provide formula

• History of recurrent infection or underlying illness/treatment predisposing to infection

• Patients residing, or who have resided, where tuberculosis or histoplasmosis is endemic

• Pre-existing or recent onset CNS demyelinating disorders

• History of lymphoma

• Geri: risk of infection/malignancy

• OB: Use only if clearly needed

• Pedi: Safety not established

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