Implementation

• High Alert: Fatalities have occurred with chemotherapeutic agents. Before administering, clarify all ambiguous orders; double check single, daily, and course-of-therapy dose limits; have second practitioner independently double check original order, calculations and infusion pump settings. Do not confuse aldesleukin (Proleukin) which is often referred to as interleukin 2, with oprelvekin (Neumega), which is referred to as interleukin 11. Aldesleukin should be administered only in a hospital setting with intensive care facilities

• Intermittent Infusion: Reconstitute each vial with 1.2 ml of sterile water for injection for a concentration of 18 million IU (1.1 mg)/ml. Direct the sterile water at the side of the vial during reconstitution and swirl contents gently to prevent excessive foaming. Do not shake. Solution should be clear and colorless to slightly yellow. Administer within 48 hr of reconstitution. Discard unused portion

» Dilute reconstituted dose in 50 ml of D5W. Do not reconstitute or dilute with bacteriostatic water for injection, 0.9% NaCl, or albumin

» Do not use an in-line filter during administration of aldesleukin

• Rate: Infuse each dose over 15 min

• Y-Site Compatibility:

» amphotericin B

» calcium gluconate

» diphenhydramine

» dopamine

» fluconazole

» foscarnet

» heparin

» magnesium sulfate

» metoclopramide

» ondansetron

» potassium chloride

» ranitidine

» thiethylperazine

» trimethoprim/sulfamethoxazole

• Y-Site Incompatibility:

» ganciclovir

» lorazepam

» pentamidine

» prochlorperazine

» promethazine,

• Additive Incompatibility: Do not mix with other drugs

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