Pharmacokinetics

Absorption: IV administration results in complete bioavailability

Distribution: Rapidly distributes to intravascular, extracellular space; 70% is taken up by the liver, kidneys, and lungs

Metabolism and Excretion: Metabolized to amino acids by renal tubular cells

Half-life: 85 min

TIME/ACTION PROFILE (tumor regression after completion of first course)

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