Contraindication/Precautions

Contraindicated in:

• Hypersensitivity to aldesleukin or mannitol

• Cross-sensitivity to Escherichia coli— derived proteins may occur

• Patients with any history of cardiac or pulmonary disease as assessed by abnormal thallium stress testing or abnormal pulmonary function testing

• Patients who have experienced any of the following toxicities during previous courses of aldesleukin—sustained ventricular tachycardia (>=5 beats), angina pectoris or MI as indicated by ECG changes, respiratory problems requiring more than 72 hr of intubation, pericardial tamponade, renal toxicity requiring more than 72 hr of dialysis, CNS dysfunction consisting of more than 48 hr of coma or psychosis, intractable seizures, bowel perforation or ischemia, GI bleeding requiring surgical intervention

• Patients who have had allograft organ transplantation (increased risk of rejection)

• Patients with a history of cardiovascular, respiratory, hepatic, or renal disease

• Patients with a history of seizures or suspected CNS metastases (symptoms may be exaggerated and seizures may occur)

• Patients with child-bearing potential

• OB: Lactation: Pedi: Safety not established

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