Pharmacokinetics

Absorption: Poorly absorbed (0.6–0.8%) after oral administration

Distribution: Transiently distributes to soft tissue, then distributes to bone

Metabolism and Excretion: Excreted in urine

Half-life: 10 yr (reflects release of drug from skeleton)

TIME/ACTION PROFILE (inhibition of bone resorption)

ROUTE	ONSET	PEAK	DURATION
PO	1 mo	3–6 mo	3 wk–7 mo†

†After discontinuation of alendronate

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