Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Moderate to severe hepatic impairment

• Potent inhibitors of the CYP3A4 enzyme system

• Concurrent use of other alpha-adrenergic blocking agents

• Severe renal impairment

• OB: No indications for women and children

• Congenital or acquired QTc prolongation or concurrent use of other drugs known to prolong QTc

• Mild hepatic impairment

• Geri: Consider age-related changes in body mass, cardiac, renal and hepatic function when prescribing

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