Pharmacokinetics

Absorption: Well absorbed (90%) from the GI tract; absorption is slower with extended-release tablets

Distribution: Widely distributed, crosses blood-brain barrier. Probably crosses the placenta and enters breast milk. Accumulation is minimal

Metabolism and Excretion: Metabolized by the liver (CYP3A4 enzyme system) to an active compound that is subsequently rapidly metabolized

Half-life: 12–15 hr

TIME/ACTION PROFILE (sedation)

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