Interactions

Drug-Drug

• Alcohol, antidepressants, other benzodiazepines, antihistamines, and opioid analgesics —concurrent use results in CNS depression

• Hormonal contraceptives, disulfiram, fluoxetine, isoniazid, metoprolol, propoxyphene, propranolol, valproic acid, CYP3A4 inhibitors (erythromycin, ketoconazole, itraconazole, fluvoxamine, cimetidine, nefazodone) metabolism of alprazolam, blood levels and its actions (dose adjustments may be necessary)

• May efficacy of levodopa

• CYP3A4 inducers (rifampin, carbamazepine, or barbiturates) metabolism and effects of alprazolam

• Sedative effects may be by theophylline

• Cigarette smoking blood levels and effects

Drug-Natural Products
Kava-kava, valerian, or chamomile can CNS depression

Drug-Food
Concurrent ingestion of grapefruit juice blood levels

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