Pharmacokinetics

Absorption: Well absorbed following oral administration. Requires metabolism for conversion to antineoplastic compounds

Distribution: Reaches high concentrations in liver, kidney, and small intestine. Poor penetration into brain

Metabolism and Excretion: Mostly metabolized by the liver to compounds with antineoplastic activity

Half-life: 4.7–10.2 hr

TIME/ACTION PROFILE (effects on blood counts)

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