Implementation

• Antacids cause premature dissolution and absorption of enteric-coated tablets and may interfere with absorption of other oral medications. Separate administration of aluminum hydroxide and oral medications by at least 1–2 hr

» Tablets must be chewed thoroughly before swallowing to prevent their entering small intestine in undissolved form. Follow with a glass of water

» Shake liquid preparations well before pouring. Follow administration with water to ensure passage into stomach

» Liquid dosage forms are considered more effective than tablets

• Hypophosphatemic: For phosphate lowering, follow dose with full glass of water or fruit juice

• Antacid: May be given in conjunction with magnesium-containing antacids to minimize constipation, except in patients with renal failure. Administer 1 and 3 hr after meals and at bedtime for maximum antacid effect

» For treatment of peptic ulcer, aluminum hydroxide may be administered every 1–2 hr while the patient is awake or diluted with 2–3 parts water and administered intragastrically every 30 min for 12 or more hr per day. Physician may order NG tube clamped after administration

» For reflux esophagitis, administer 15 ml 20–40 min after meals and at bedtime

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