Pharmacokinetics

Absorption: With chronic use, small amounts of aluminum are systemically absorbed

Distribution: If absorbed, aluminum distributes widely, crosses the placenta, and enters breast milk. Concentrates in the CNS with chronic use

Metabolism and Excretion: Mostly excreted in feces. Small amounts absorbed are excreted by the kidneys

Half-life: Unknown

TIME/ACTION PROFILE

ROUTE	ONSET	PEAK	DURATION
PO†	hr–days	days–wk	days
PO‡	15–30 min	30 min	30 min–3 hr

†Hypophosphatemic effect
‡Antacid effect

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