Route/Dosage

Parkinson's Disease

• PO (Adults): 100 mg 1–2 times daily (up to 400 mg/day).

• PO (Adults and Children >12 yr):
Treatment—200 mg/day as a single dose or 100 mg bid (not >100 mg/day in geriatric patients);
Prophylaxis—100 mg/day in 1–2 divided doses.

• PO (Children 10–12 yr): 100 mg q 12 hr
or 5 mg/kg/day in 1–2 divided doses; not to exceed 200 mg/day.

• PO (Children 1–9 yr): 5 mg/kg/day in 1–2 divided doses; not to exceed 150 mg/day.

• PO (Adults):
CCr 30–50 ml/min—200 mg on the first day, then 100 mg once daily;
CCr 15–29 ml/min—200 mg on the first day, then 100 mg every other day;
<15 ml/min or hemodialysis patients—200 mg once every 7 days.

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