Implementation

IV Adminstration:

• Intermittent Infusion:

Diluent: Reconstitute with 9.7 ml of sterile 0.9% NaCl. Dilute further with 0.9% NaCl. Do not administer solutions that are discolored or contain particulate matter. Solution is stable for 5 hr at room temperature or 24 hr if refrigerated.
Concentration: Adults: dilute dose to a final volume of 50 ml; Children: 5–40 mg/ml

• Rate:
For renal toxicity: Administer over 15 min within 30 min before chemotherapy administration. Longer infusion times are not as well tolerated. For xerostomia: Administer over 3 min starting 15–30 min prior to radiation therapy

• Y-Site Compatibility:

» amikacin

» aminophylline

» ampicillin

» ampicillin/sulbactam

» aztreonam

» bleomycin

» bumetanide

» buprenorphine

» butorphanol

» calcium gluconate

» carboplatin

» carmustine

» cefazolin

» cefotaxime

» cefotetan

» cefoxitin

» ceftazidime

» ceftizoxime

» ceftriaxone

» cefuroxime

» cimetidine

» ciprofloxacin

» clindamycin

» cyclophosphamide

» cytarabine

» dacarbazine

» dactinomycin

» daunorubicin

» diphenhydramine

» dobutamine

» docetaxel

» dopamine

» doxorubicin

» doxycycline

» droperidol

» enalaprilat

» etoposide

» famotidine

» floxuridine

» fluconazole

» fludarabine

» fluorouracil

» furosemide

» gentamicin

» gemcitabine

» granisetron

» haloperidol

» heparin

» hydrocortisone

» hydromorphone

» idarubicin

» ifosfamide

» imipenem/cilastatin

» leucovorin

» lorazepam

» magnesium sulfate

» mannitol

» mechlorethamine

» meperidine

» mesna

» methotrexate

» methylprednisolone

» metoclopramide

» metronidazole

» mitomycin

» mitoxantrone

» morphine

» nalbuphine

» ondansetron

» pemetrexed

» piperacillin

» potassium chloride

» promethazine

» ranitidine

» sodium bicarbonate

» streptozocin

» teniposide

» thiotepa

» ticarcillin/clavulanate

» tobramycin

» trimethoprim/sulfamethoxazole

» trimetrexate

» vancomycin

» vinblastine

» vincristine

» zidovudine

• Y-Site Incompatibility:

» acyclovir

» amphotericin B

» cefoperazone

» chlorpromazine

» cisplatin

» ganciclovir

» prochlorperazine

• Additive Incompatibility:
Do not mix with other solutions or medications

amifostine is a sample topic found in Davis's Drug Guide. All other sections of this record are viewable by clicking on the index in the left column, or by clicking on "Display all Sections" in the "Content Manager".

To find other Davis's Drug Guide topics, please login or purchase a subscription.