Action

Converted by alkaline phosphatase in tissue to a free thiol compound that binds and detoxifies damaging metabolites of cisplatin and reactive oxygen species generated by radiation

Therapeutic Effect(s):

• Decreased renal damage from cisplatin

• Decreased severity of xerostomia following radiation for head and neck cancer

amifostine is a sample topic found in Davis's Drug Guide. All other sections of this record are viewable by clicking on the index in the left column, or by clicking on "Display all Sections" in the "Content Manager".

To find other Davis's Drug Guide topics, please login or purchase a subscription.