Route/Dosage

Acute Bleeding Syndromes due to Elevated Fibrinolytic Activity

• PO (Adults): 5 g 1st hr, followed by 1–1.25 g q hr for 8 hr or until hemorrhage is controlled; or 6 g over 24 hr after prostate surgery (not > 30 g/day).

• IV (Adults): 4–5 g over 1st hr, followed by 1 g/hr for 8 hr or until hemorrhage is controlled; or 6 g over 24 hr after prostate surgery (not >30 g/day).

• PO, IV (Children): 100 mg/kg or 3 g/m² over 1st hr, followed by continuous infusion of 33.3 mg/kg/hr; or 1 g/m²/hr (total dosage not >18 g/m²/24 hr).

• PO (Adults):
To follow IV—3 g q 2 hr (36 g/day). If no surgery is performed, continue for 21 days after bleeding stops, then decrease to 2 g q 2 hr (24 g/day) for 3 days, then 1 g q 2 hr (12 g/day) for 3 days.

• IV (Adults): 36 g/day for 10 days followed by PO.

• PO (Adults): 75 mg/kg (up to 6 g) immediately after procedure, then q 6 hr for 7–10 days; syrup may also be used as an oral rinse of 1.25 g (5 ml) 4 times a day for 7–10 days.

• IV, PO (Children):
Also for epistaxis—50–100 mg/kg/dose administered IV every 6 hr for 2–3 days starting 4 hr before the procedure. After completion of IV therapy, aminocaproic acid should be given as 50–100 mg/kg/dose orally every 6 hr for 5–7 days.

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